Research Fellow in Structural Biology

Overview

Are you an ambitious researcher looking for your next challenge? Do you have an established background in Structural Biology, particularly Cryo-Electron Microscopy (cryo-EM), NMR, or HDX-MS? Do you want to further your career in one of the UK’s leading research-intensive universities?

Job Overview

Based in the laboratories of Professor Alex Breeze and Dr. Stephen Muench at the Astbury Centre for Structural Molecular Biology, you will work on an exciting project deciphering the chaperone interaction cycle of fibroblast growth factor receptors (FGFRs). The project is funded for 9 months by the Biotechnology and Biological Sciences Research Council (BBSRC) and will involve:

• Solving high-resolution structures of complexes of FGFR intracellular domain with HSP90 and Cdc37 chaperone components using cryo-EM.
• Investigating dynamics and interaction epitopes using NMR spectroscopy and hydrogen-deuterium exchange (HDX-MS).

Facilities and Training

Exceptional facilities and training are available in Leeds to support the project, including:

• Two Titan Krios electron microscopes equipped with the latest detectors.
• State-of-the-art cryoprobe-equipped NMR spectrometers including Bruker Avance III HD Aeon 950 MHz.
• Waters Synapt HDMS IM-MS, HDX, and FPOP mass spectrometers.

Qualifications and Experience

You should have a PhD (or close to completion) in structural biology or a closely allied discipline, with experience in cryo-EM and potentially also NMR spectroscopy and/or structural MS, as well as protein expression, purification, and labelling for the study of large proteins.

Sponsorship Information

Please note that this post may be suitable for sponsorship under the Skilled Worker visa route but first-time applicants might need to qualify for salary concessions. For research and academic posts, University of Leeds will consider eligibility under the Global Talent visa.

Benefits

What University of Leeds offer in return:

• 26 days holiday plus approximately 16 Bank Holidays/days that the University is closed by custom (including Christmas) – that’s 42 days a year!
• Generous pension scheme plus life assurance – the University contributes 14.5% of salary.
• Health and Wellbeing: Discounted staff membership options at The Edge, University of Leeds's state-of-the-art campus gym, with a pool, sauna, climbing wall, cycle circuit, and sports halls.
• Personal Development: Access to courses run by University of Leeds's Organisational Development & Professional Learning team.
• Access to on-site childcare, shopping discounts, and travel schemes are also available.
• And much more!